Study on liver protection and hepatotoxicity of saikosaponin a based on zebrafish model.
10.19540/j.cnki.cjcmm.20190520.205
- Author:
Qing XIA
1
;
Li-Wen HAN
1
;
Yun ZHANG
1
;
Qiu-Xia HE
1
;
Shan-Shan ZHANG
1
;
Jing-Jing GAO
1
;
Ke-Chun LIU
1
;
Peng-Fei TU
2
Author Information
1. Biology Institute,Qilu University of Technology (Shandong Academy of Sciences) Ji'nan 250103,China.
2. State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University Beijing 100191,China.
- Publication Type:Journal Article
- Keywords:
hepatotoxicity;
liver protection;
saikosaponin a;
zebrafish
- MeSH:
Animals;
Chemical and Drug Induced Liver Injury;
Fatty Liver, Alcoholic;
drug therapy;
Oleanolic Acid;
analogs & derivatives;
pharmacology;
toxicity;
Saponins;
pharmacology;
toxicity;
Zebrafish
- From:
China Journal of Chinese Materia Medica
2019;44(13):2662-2666
- CountryChina
- Language:Chinese
-
Abstract:
Bupleuri Radix has both liver protection and hepatotoxicity. Saponins are the main pharmacodynamic and toxic components of Bupleuri Radix. Based on zebrafish physical model and the model of alcoholic fatty liver( AFL) pathology,the liver toxic and protective effect of saikosaponin a( SSa) were assessed. The results indicated that 1. 77 μmol·L-1 SSa showed protective effect to AFL zebrafish. 5. 30 μmol·L-1 SSa was hepatotoxic to healthy zebrafish,but it showed protective effect to AFL zebrafish. 5. 62 μmol·L-1 SSa was hepatotoxic to healthy and AFL zebrafish. This study is benefit for clinical safety of saikosaponin a.
