Network pharmacology-based study on mechanisms of Danhong Injection in treatment of aspirin resistance.
10.19540/j.cnki.cjcmm.20190215.001
- Author:
Run-Min LAI
1
;
Jian-Qing JU
1
;
Yi-Han ZHAO
1
;
Hao XU
2
Author Information
1. Graduate School,Beijing University of Chinese Medicine Beijing 100029,China.
2. Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China.
- Publication Type:Journal Article
- Keywords:
Carthami Flos;
Danhong Injection;
Salviae Miltiorrhizae Radix et Rhizoma;
aspirin resistance;
network pharmacology
- MeSH:
Aspirin;
pharmacology;
Drug Resistance;
Drugs, Chinese Herbal;
pharmacology;
Medicine, Chinese Traditional;
Rhizome
- From:
China Journal of Chinese Materia Medica
2019;44(13):2719-2726
- CountryChina
- Language:Chinese
-
Abstract:
This paper aims to discuss the potential targets,pathways and possible mechanisms of Danhong Injection in treatment of aspirin resistance by using network pharmacology concept and network analysis technique. Active ingredients and potential targets of Danhong Injection were collected from TCMSP database and the ingredients were further screened based on their topological characteristics. The active ingredients with nodal degree of freedom≥9 were selected as the main active ingredients. Targets related to aspirin resistance were collected from Genecards database. Drug-active ingredient-target-disease network was constructed by using Cytoscape3. 7. 0,and Funrich 3. 1. 3 software was used for gene enrichment analysis. Sixty main active ingredients were screened out from 110 active ingredients of Danhong Injection,including 51 ingredients in Salviae Miltiorrhizae Radix et Rhizoma and 11 ingredients in Carthami Flos,2 of which were both in Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos. In addition,159 potential targets were collected. The results of gene enrichment analysis showed that Danhong Injection could improve aspirin resistance mainly through21 pathways involving coagulation process,inflammatory response and metabolism. This study revealed the effects of Danhong Injection for improving aspirin resistance in multi-component,multi-target and multi-pathway means mainly through regulation in coagulation process,inflammatory response and metabolism,providing more abundant information and basis for subsequent research and experimental work.
