Research progress and secondary development ideas of Astragali Radix polysaccharides for injection.
10.19540/j.cnki.cjcmm.20190321.303
- Author:
Shu-Ying LI
1
;
Ke LI
2
;
Xue-Mei QIN
2
;
Xian-Rong LI
3
;
Yu-Guang DU
4
Author Information
1. Modern Research Center for Traditional Chinese Medicine,Shanxi University Taiyuan 030006,China College of Chemistry and Chemical Engineering,Shanxi University Taiyuan 030006,China Key Laboratory of Effective Substances Research and Utilization in Traditional Chinese Medicine of Shanxi Province Taiyuan 030006,China.
2. Modern Research Center for Traditional Chinese Medicine,Shanxi University Taiyuan 030006,China Key Laboratory of Effective Substances Research and Utilization in Traditional Chinese Medicine of Shanxi Province Taiyuan 030006,China.
3. Shanxi Jianshuo Food and Drug Research Institute Co.,Ltd. Taiyuan 030000,China Shanxi Academy of Traditional Chinese Medicine Taiyuan 030000,China.
4. Institute of Process Engineering,Chinese Academy of Sciences Beijing 100190,China.
- Publication Type:Journal Article
- Keywords:
Astragali Radix polysaccharide for injection;
oligosaccharide;
polysaccharide receptor theory;
secondary development
- MeSH:
Astragalus Plant;
chemistry;
Drugs, Chinese Herbal;
Humans;
Medicine, Chinese Traditional;
Plant Roots;
chemistry;
Polysaccharides;
pharmacology
- From:
China Journal of Chinese Materia Medica
2019;44(13):2736-2741
- CountryChina
- Language:Chinese
-
Abstract:
Astragali Radix( AR) polysaccharide for injection( Guoyao Zhunzi Z20040086) is a traditional Chinese medicine for intravenous powder injection developed by Shanxi Academy of Traditional Chinese Medicine in early 1990 s by taking advantage of AR resources in Shanxi province. The effective parts of AR polysaccharides were obtained by advanced technology. The hemogram of patients with radiotherapy and chemotherapy showed alleviations in clinic. However,due to the technical bottleneck in separation of the complex polysaccharides mixture and the difficulties in accurate measurement of the polysaccharide structures,the pharmacodynamic mechanism of the drug remained unclear,and the side effect was hard to control. In recent years,the theoretical studies for polysaccharide receptors have indicated that when polysaccharides bound to protein receptors,only the oligosaccharide fragments of the polysaccharide molecule bound to the receptors,and one or more active sites of oligosaccharide fragments may existed in the polysaccharide molecule.Therefore,the active center of polysaccharides can be studied based on the level of oligosaccharides through degradation of the polysaccharides,which provided a new strategy for breaking through the bottleneck in polysaccharide structure determination. Therefore,this paper reviews the current status of studies for AR polysaccharides for injection,the polysaccharide receptors theory and successful cases,in order to propose the secondary development ideas of AR polysaccharides for injection. The study results will lay a material foundation for the development of new drugs of polysaccharides from traditional Chinese medicine,and provide a basis for the resolution of international difficulties in quality control of polysaccharide drugs and molecular models,so as to further study of glycobiology,and enrich the polysaccharide receptors theory.
