Efficacy and safety of Gantaishu Capsules for viral B hepatitis:a systematic review and Meta-analysis.
10.19540/j.cnki.cjcmm.20190321.502
- Author:
De-Heng LI
1
;
Po HUANG
2
;
Bo LI
2
;
Xiu-Hui LI
3
Author Information
1. Hainan West Central Hospital Danzhou 571700,China.
2. Beijing Hospital of Traditional Chinese Medicine,Capital Medical University Beijing 100010,China.
3. Beijing You'an Hospital Affiliated to Capital Medical University Beijing 100069,China.
- Publication Type:Journal Article
- Keywords:
Gantaishu Capsules;
efficacy;
safety;
systematic review;
viral B hepatitis
- MeSH:
Antiviral Agents;
therapeutic use;
Capsules;
DNA, Viral;
blood;
Drugs, Chinese Herbal;
therapeutic use;
Hepatitis B e Antigens;
blood;
Hepatitis B, Chronic;
drug therapy;
Humans;
Quality of Life
- From:
China Journal of Chinese Materia Medica
2019;44(13):2858-2864
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the efficacy and safety of Gantaishu Capsules in the treatment of viral B hepatitis. The randomized controlled trials( RCT) retrieved from Cochrane Library,PubMed,Sino Med,CNKI,Wan Fang and VIP were enrolled. The methodology quality of the included studies was evaluated,and a Meta-analysis was performed using Rev Man 5. 3 software. A total of six randomized controlled trials were included. Meta-analysis results showed that the similarities in the negative conversion rate of HBe Ag( RR = 2. 09,95%CI[0. 90,4. 85],P = 0. 09,I2= 0%),the HBV-DNA negative rate( RR = 1. 49,95% CI[0. 56,3. 95],P = 0. 43,I2= 0%) and the changes in ALT levels before and after treatment( RR =-6. 28,95%CI[-72. 83,60. 27],P = 0. 85,I2= 99%),with no statistical difference. In terms of quality of life,Gantaishu Capsules can significantly alleviate the symptoms of hepatitis B patients,with less adverse reactions. Gantaishu Capsules and Dongbao Gantai Tablets were similar in antiviral effect. In this term,Gantaishu Capsules was superior to Dangfei Liganning Capsules. It can significantly alleviate the symptoms of chronic hepatitis B patients,with a good clinical safety.Therefore,it can be applied in the case of syndrome differentiation and treatment. In view of the low quality of the included studies,more high-quality clinical trials were required to confirm its efficacy.
