Effect of Fuyanshu Capsules combined with antibiotics on inflammatory factors in patients with pelvic inflammatory disease.
10.19540/j.cnki.cjcmm.20190305.003
- Author:
Xiao-Ling FENG
1
;
Sha JIANG
2
;
Jing CHEN
2
;
Xun LIU
2
;
Yang ZHANG
1
;
Lu CHEN
1
Author Information
1. the First Affiliated Hospital of Heilongjiang University of Chinese Medicine Harbin 150040,China.
2. First Clinical Medical College of Heilongjiang University of Chinese Medicine Harbin 150040,China.
- Publication Type:Journal Article
- Keywords:
Fuyanshu Capsules;
IL-10;
IL-1β;
chronic pelvic pain;
pelvic inflammatory disease;
recurrence;
symptoms and signs
- MeSH:
Anti-Bacterial Agents;
therapeutic use;
Capsules;
Drugs, Chinese Herbal;
therapeutic use;
Female;
Humans;
Interleukin-10;
blood;
Interleukin-1beta;
blood;
Levofloxacin;
Medicine, Chinese Traditional;
Metronidazole;
Pelvic Inflammatory Disease;
drug therapy
- From:
China Journal of Chinese Materia Medica
2019;44(12):2637-2643
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effect of Fuyanshu Capsules combined with Western medicine antibiotics on symptoms and inflammatory factors IL-10 and IL-1β in patients with pelvic inflammatory disease and its possible mechanism. Totally 112 patients with pelvic inflammatory disease of damp-heat stagnation treated since April 2017 to April 2018 were randomly divided into treatment group( group A,57 cases) and control group( group B,55 cases). The treatment group was given Fuyanshu Capsules for 56 d,and levofloxacin hydrochloride tablets and metronidazole tablets for 14 d. The control group was given Fuyanshu Capsules as its analogue. The curative rate,effective rate and inefficiency,serum IL-10 and IL-1β levels were compared between the two groups. The curative effect was evaluated with McCormack score and traditional Chinese medicine( TCM) syndrome score. The recurrence rate and chronic pelvic pain were followed up after one menstrual cycle. It was found that the curative rate and effective rate of group A were higher than those of group B after treatment. After 28 d of treatment,there was a difference in the effective rate of TCM syndrome score between group A and group B( 62. 71% vs 8. 47%,P < 0. 01). After 56 d of treatment,serum IL-10 increased,while IL-1β decreased in group A,which was significantly different from that in group B( P<0. 01). The recurrence rate of PID and chronic pelvic pain in group A were significantly lower than those in group B( P<0. 01). The results showed that Fuyanshu Capsules combined with levofloxacin and metronidazole could alleviate the clinical symptoms and signs of chronic pelvic inflammation of damp-heat stagnation type,reduce the recurrence rate of pelvic inflammation,relieve pelvic pain,and alleviate the inflammation status of patients by regulating the expression of IL-10 and IL-1β in peripheral serum.
