Optimized model for formulation prescription of traditional Chinese medicine buccal tablets based on temporal dominant description of sensations combined with multivariate statistical analysis:an example of Compound Caoshanhu Buccal Tablets.
10.19540/j.cnki.cjcmm.20190410.303
- Author:
Pan LI
1
;
Ding-Kun ZHANG
1
;
Jun-Zhi LIN
2
;
Xue HAN
1
;
Xiu-Mei KE
1
;
Li HAN
1
;
Ming YANG
3
;
Hong-Ning LIU
3
Author Information
1. Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology,Pharmacy College,Chengdu University of Traditional Chinese Medicine Chengdu 611137,China.
2. Central Laboratory,Affiliated Hospital to Chengdu University of Traditional Chinese Medicine Chengdu 610072,China.
3. State Key Laboratory of Innovative Medicines and Energy-efficient and Cost-reducing Pharmaceutical Equipment,Jiangxi University of Traditional Chinese Medicine Nanchang 330004,China.
- Publication Type:Journal Article
- Keywords:
Compound Caoshanhu Buccal Tablets;
formulation prescription;
multivariate statistical analysis;
taste;
temporal dominance;
traditional Chinese medicine buccal tablets
- MeSH:
Drug Compounding;
Humans;
Medicine, Chinese Traditional;
Sensation;
Solubility;
Tablets;
Taste
- From:
China Journal of Chinese Materia Medica
2019;44(14):3035-3041
- CountryChina
- Language:Chinese
-
Abstract:
The taste is the key to the research and design for formulation prescription of traditional Chinese medicine buccal tablets( TCMBTs). TCMBTs are dissolved in the oral cavity in parallel with the release of the drug,providing a sufficient " time window" for the perception of various basic taste,tactile and retention. The overall taste is the result of competitive inhibition,comprehensive superposition and dynamic change of multiple tastes. Traditional evaluation methods rely mostly on recalled experience score,difficult to reflect the dynamic changes of taste for buccal tablets. Therefore,it is urgent to establish a new optimized model for taste evaluation and formulation prescription according to the formulation characteristics of TCMBTs. To this end,this paper proposed for the first time to construct a research method for the optimal formulation of TCMBTs based on temporal dominant description of sensations combined with multivariate statistical analysis: the sensory test of volunteers was carried out by temporal dominant description analysis method,and elements separation was conducted for the time and taste in the process of inclusion to form a temporal dominant descriptive score of multi-time points and multi-sensory attributes. Finally,the optimal formulation was obtained by multivariate statistical analysis. Taking the formulation prescription of Compound Caoshanhu Buccal Tablets as an example,the research ideas of this method were explained,and the optimal formulation prescription was obtained as follows,Glabrous Sarcandra Extract of 20. 0 g,mannitol of 24. 0 g,microcrystalline cellulose of 12. 0 g,aspartame of 1. 0%,menthol of 0. 7%,and menthol oil of 0. 7%. This study provides a new method for the taste evaluation and formulation research of TCMBTs,providing a new idea for the fine manufacturing and innovative development of TCM buccal tablets in the new era.
