Chemical compositions from roots of Erythrina corallodendron.
10.19540/j.cnki.cjcmm.20190520.204
- Author:
Wen-Qian DING
1
;
Guo-Ru SHI
2
;
Shi-Shan YU
2
Author Information
1. Hunan University of Chinese Medicine Changsha 530200,China.
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050,China.
- Publication Type:Journal Article
- Keywords:
Erythrina;
Erythrina corallodendron;
chemical composition;
erythrina alkaloid;
pharmacological activity
- MeSH:
Antioxidants;
analysis;
Chromatography, High Pressure Liquid;
Erythrina;
chemistry;
Microsomes, Liver;
drug effects;
Phytochemicals;
analysis;
Plant Extracts;
analysis;
Plant Roots;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(14):3064-3069
- CountryChina
- Language:Chinese
-
Abstract:
This project is to investigate chemical compositions from the roots of Erythrina corallodendron. Through the methods of silica gel,ODS,Sephadex LH-20 column chromatography and preparative HPLC,15 compounds were isolated from the 95% ethanol extract of the roots of E. corallodendron. Based on spectroscopic techniques,the structures of these compounds were identified as 10,11-dioxoerythraline( 1),erythrinine( 2),erythraline( 3),11-methoxyerythraline( 4),cristanines B( 5),erythratine( 6),erysotrine( 7),medioresinol( 8),( ±)-ficusesquilignan A( 9),( +)-pinoresinol( 10),nicotinic acid( 11),dibutyl phthalate( 12),vanillic acid( 13),3-hydroxy-1-( 4-hydroxy-3-methoxyphenyl)-1-propanone( 14),and syringic acid( 15). Compounds 8-10 are isolated from genus Erythrina for the first time and all compounds are isolated from E. corallodendron for the first time. Furthermore,this paper screened the antioxidant and cytotoxic activities of the compounds using models of liver microsomal oxidation inhibition and MTT.
