Analysis on mechanisms and medication rules of herbal prescriptions for nonalcoholic fatty liver disease based on methods of data mining and biological information.
10.19540/j.cnki.cjcmm.20190110.001
- Author:
Jing DING
1
;
Bin ZHANG
1
;
Pei-Ji WANG
1
;
Guo-Nong HE
2
;
Dong-Mei WEI
1
;
Jia-Lu DING
1
;
Bang-Cai WANG
2
Author Information
1. Department of Gastroenterology,Ningbo Hospital of Traditional Chinese Medicine Ningbo 315012,China.
2. Science and Education Department,Ningbo Hospital of Traditional Chinese Medicine Ningbo 315012,China.
- Publication Type:Journal Article
- Keywords:
biological information;
data mining;
mechanisms of herbal prescriptions;
medication rules of herbal prescriptions;
nonalcoholic fatty liver disease
- MeSH:
Data Mining;
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Medicine, Chinese Traditional;
Meridians;
Non-alcoholic Fatty Liver Disease;
drug therapy;
Randomized Controlled Trials as Topic;
Signal Transduction
- From:
China Journal of Chinese Materia Medica
2019;44(8):1689-1695
- CountryChina
- Language:Chinese
-
Abstract:
To explore the medication rules of herbal prescriptions for nonalcoholic fatty liver disease,and analyze the possible drug targets and interactions,in order to explore the mechanisms of the herbs. Randomized controlled trials of herbal prescriptions for treating nonalcoholic fatty liver disease were collected from CNKI,Wan Fang,VIP,Sino Med and PubMed databases. The properties,flavors and meridian tropism of herbs were analyzed by using systematic cluster analysis method with SPSS 19. 0 software. Subsequently,the association rules of herbs were analyzed by using Clementine 12. 0 software. Finally,the interactions between targets and relevant signaling pathways were analyzed by Traditional Chinese Medicine Systems Pharmacology Database(TCMSP),Search Tool for the Retrieval of Interacting Genes/Proteins(STRING) and Kyoto Encyclopedia of Genes and Genomes(KEGG). In the 88 prescriptions screened out,the commonly used herbs were Salvia miltiorrhiza,Bupleurum chinense,Alisma orientale,and Crataegus pinnatifida,and the potential signaling pathways were PPAR signaling pathway and calcium signaling pathway. The results showed that the main effects of herbal prescriptions were to improve blood flow/clear blood stasis,clear heatiness/dampness,promote digestion and strengthen spleen. And its mechanism of action may be achieved through the regulation of PPAR signaling pathway and calcium signaling pathway.
