A new lupane-type triterpenoid from Dichroa hirsuta.
10.19540/j.cnki.cjcmm.20190222.007
- Author:
Lu-Fen LENG
1
;
Chun-Die YI
1
;
Wen-Kai ZHAO
1
;
Jun-Lin YIN
1
;
Guang-Zhi ZENG
1
Author Information
1. YMU-HKBU Joint Laboratory of Traditional Natural Medicine,Key Laboratory of Ethnic Medicine Resource Chemistry,State Ethnic Affairs Commission,Ministry of Education of China,Yunnan Minzu University Kunming 650000,China.
- Publication Type:Journal Article
- Keywords:
Dichroa Lour.;
Dichroa hirsuta;
Nrf2-ARE signaling pathway;
cinnamic acid;
coumarin;
lupane-type triterpenoid
- MeSH:
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
Hydrangea;
chemistry;
Phytochemicals;
isolation & purification;
pharmacology;
Triterpenes;
isolation & purification;
pharmacology
- From:
China Journal of Chinese Materia Medica
2019;44(9):1829-1835
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents from methanol extract of Dichroa hirsuta were separated by silica gel and Sephadex LH-20 column chromatography,high pressure preparative liquid chromatography( HPLC) and recrystallization. Their structures were elucidated by NMR and MS. Nine compounds were obtained and their structures were identified as 3β,21α-O-diacetyl-lup-9( 11)-en-7β-ol( 1),( Z)-methyl p-hydroxycinnamate( 2),cis-p-coumaric acid ethyl ester( 3),( E)-methyl p-hydroxycinnamate( 4),trans-p-coumaric acid ethyl ester( 5),4( 3 H)-quinazolinone( 6),7-hydroxycoumarin( 7),hydrangenol( 8) and thunberginol C( 9). Compound 1 is a new lupane-type triterpenoid,and compounds 1-5,8-9 were firstly isolated from this plant. Dual reporter assay results showed that compounds 2-5 could activate the Nrf2-ARE signaling pathway.
