Study on effect of extract from Tibetan medicine Urtica hyperborean on anti-prostatic hyperplasia.
10.19540/j.cnki.cjcmm.20190304.004
- Author:
Ri-Na SU
1
;
Rong-Rui WEI
1
;
Wei-Zao LUO
2
;
Ji-Xiao ZHU
1
;
Lu WANG
1
;
Guo-Yue ZHONG
1
Author Information
1. Research Center for Traditional Chinese Medicine Research and Ethnic Minority Medicine,Jiangxi University of Traditional Chinese Medicine Nanchang 330004,China.
2. Chongqing Academy of Chinese Materia Medica Chongqing 400065,China.
- Publication Type:Journal Article
- Keywords:
Bcl-2;
Urtica hyperborean;
dihydrotestosterone(DHT);
epidermal growth factor(EGF);
mechanism of action;
prostate hyperplasia
- MeSH:
Animals;
Dihydrotestosterone;
blood;
Epidermal Growth Factor;
blood;
Male;
Medicine, Tibetan Traditional;
Mice;
Plant Extracts;
pharmacology;
Prostatic Hyperplasia;
chemically induced;
drug therapy;
Proto-Oncogene Proteins c-bcl-2;
metabolism;
Testosterone Propionate;
Urticaceae;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(9):1953-1959
- CountryChina
- Language:Chinese
-
Abstract:
In this study,mouse models of benign prostatic hyperplasia induced by subcutaneous injection of testosterone propionate was used to investigate the therapeutic effect and mechanism of Urtica hyperborean( UW) extracts on prostate hyperplasia in mice. The effects of UW extracts on prostate index,serum epidermal growth factor( EGF) and dihydrotestosterone( DHT) in model mice were observed,and the EGF and anti-apoptotic factor( Bcl-2) mRNA expression levels were detected as well as pathological changes in prostate tissue. The results showed that the ethyl acetate extraction and alcohol soluble fraction of the UW could significantly reduce the prostate index,reduce the serum DHT and EGF levels( P<0. 01),and significantly decrease the EGF and Bcl-2 mRNA expression( P<0. 01),significantly improved the morphological structure of prostate tissue. The above results confirmed that ethyl acetate extract and alcohol-soluble parts of UW have a good preventive effect on mice prostatic hyperplasia model,and its mechanism may be to reduce androgen levels by regulating polypeptide growth factors and/or inhibiting cell hyperproliferation and promoting apoptosis. This study laid the foundation for the further research on UW.
