Establishment of "quantitative analysis of multi-components by single marker" method for phenolic acids in compound Danshen Tablets and its application in mass transfer law.
10.19540/j.cnki.cjcmm.20190326.304
- Author:
Zi-Yang LI
1
;
Yan-Hui KUANG
2
;
Wei-Hong FENG
3
;
Xiang-Wei LI
3
;
Dong ZHANG
3
;
Jing-Jing ZHU
3
;
Zhi-Min WANG
3
;
De-Qin WANG
2
Author Information
1. Beijing University of Chinese Medicine Beijing 100029,China National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
2. Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co.,Ltd. Guangzhou 510515,China.
3. National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
- Publication Type:Journal Article
- Keywords:
Salvia miltiorrhiza;
mass transmission;
quality control;
quantitative analysis of multi-components by single marker
- MeSH:
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
chemistry;
Hydroxybenzoates;
analysis;
Quality Control;
Salvia miltiorrhiza;
chemistry;
Tablets
- From:
China Journal of Chinese Materia Medica
2019;44(10):2059-2064
- CountryChina
- Language:Chinese
-
Abstract:
To construct a quality management model for the whole industry chain of compound Danshen Tablets,and quality control system for all key links in the production of compound Danshen Tablets. In this paper,with salvianolic acid B as internal reference substance,three batches of mix standards were prepared,and three sets of relative correlation factors between salvianolic acid B and other phenolic acids were calculated in parallel. Finally,the correlation factors are obtained on average. The quality transfer process was studied by optimizing the concentration of Salvia miltiorrhiza extract. The results showed that RSD among three sets of relative correlation factors ranged between 1. 7%-4. 1%,with no significant difference between the quantitative result of two methods. In addition,the quality transfer study showed that with the rise of the concentration temperature,the content of phenolic acid components changed,which had a significant effect on the salvianolic acid B at more than 80 ℃. It was suggested to rationally control the concentration temperature during the industrial production. The results of this study provide a methodology for the establishment of the quality control system for the whole industry chain of compound Danshen Tablets,and quality control methods for the improvement of the quality of medicinal materials and finished medicine products.
