Analysis of standard decoction of salt-processed Psoraleae Fructus.
10.19540/j.cnki.cjcmm.20190221.002
- Author:
Xiang-Wei LI
1
;
Xin-Lin LYU
2
;
Zi-Yang LI
2
;
Tong JIANG
2
;
Yong-Xin ZHANG
2
;
Jing-Jing ZHU
2
;
Ji SHI
3
Author Information
1. School of Pharmacy,Liaoning University of Traditional Chinese Medicine Dalian 116600,China Institute of Chinese Materia Medica,China Academy of Chinese Medicinal Sciences Beijing 100700,China.
2. Institute of Chinese Materia Medica,China Academy of Chinese Medicinal Sciences Beijing 100700,China.
3. School of Pharmacy,Liaoning University of Traditional Chinese Medicine Dalian 116600,China Key Laboratory of Analysis of Processing Principle,State Administration of Tradition Chinese Medicine Dalian 116600,China Liaoning Research Center of Traditional Chinese Medicine Processing Engineering Dalian 116600,China.
- Publication Type:Journal Article
- Keywords:
fingerprints;
isopsoralen;
psoralen;
salt-processed Psoraleae Fructus;
standard decoction
- MeSH:
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
analysis;
Fruit;
chemistry;
Medicine, Chinese Traditional;
Phytochemicals;
analysis;
Psoralea;
chemistry;
Quality Control
- From:
China Journal of Chinese Materia Medica
2019;44(10):2078-2083
- CountryChina
- Language:Chinese
-
Abstract:
The traditional Chinese medicine standard decoction is prepared on the basis of the theory of traditional Chinese medicine and clinical application. With reference to the modern extraction method,the single decoction of traditional Chinese medicine is prepared by the standardized process,and the establishment of its quality standards is conducive to standardizing clinical medication. This research is to set an evaluation standard for the quality of salt-processed Psoraleae Fructus standard decoction. Twelve batches of salt-processed Psoraleae Fructus standard decoctions were prepared. The contents of psoralen and isopsoralen were determined,the transfer and extract rates were calculated,and the pH value was measured; HPLC fingerprint method was established for analysis. The results of the 12 batches of samples revealed that the transfer rates of psoralen and isopsoralen were 17. 10%-26. 40%,14. 70%-22. 70%,respectively; the extract rate was between 14. 7%-27. 0%,and the pH value was between 5. 4-6. 9. Moreover,7 common chromatographic peaks were determined based on fingerprint by using similarity evaluation system for chromatographic fingerprint of traditional Chinese medicine( 2012 A).The similarities of the 12 batches of samples were analyzed and compared,and the results showed that the similarities were all higher than0. 9. In this study,the preparation method for salt-processed Psoraleae Fructus decoction was standard,with high similarities in fingerprint. This study build a convenient and reliable method of comprehensive quality evaluation,with a high precision,stability and repeatability,which can provide a reference for the quality control of salt-processed Psoraleae Fructus dispensing granules.
