A new polyketide from marine-derived Streptomyces sp.MDW-06.
10.19540/j.cnki.cjcmm.20190222.010
- Author:
Cong WANG
1
;
Zi-Yan QIU
1
;
Fu-Hou LEI
2
;
Xue-Cai TAN
2
;
Ming-Guo JIANG
3
;
Hao LI
2
;
Xiao-Yan LI
2
Author Information
1. Guangxi Colleges and Universities Key Laboratory of Utilization of Microbial and Botanical Resources,School of Marine Sciences and Biotechnology,Guangxi University for Nationalities Nanning 530006,China Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry,School of Chemistry and Chemical Engineering,Guangxi University for Nationalities Nanning 530006,China.
2. Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry,School of Chemistry and Chemical Engineering,Guangxi University for Nationalities Nanning 530006,China.
3. Guangxi Colleges and Universities Key Laboratory of Utilization of Microbial and Botanical Resources,School of Marine Sciences and Biotechnology,Guangxi University for Nationalities Nanning 530006,China.
- Publication Type:Journal Article
- Keywords:
MDW-06;
Streptomyces;
marine-derived Streptomyces sp;
secondary metabolite
- MeSH:
Chromatography;
Fermentation;
Free Radical Scavengers;
chemistry;
isolation & purification;
Magnetic Resonance Spectroscopy;
Polyketides;
chemistry;
isolation & purification;
Streptomyces;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(10):2090-2095
- CountryChina
- Language:Chinese
-
Abstract:
To isolate and identify secondary metabolites of marine-derived Streptomyces sp.MDW-06,the isolations and purifications of compounds were performed by means of column chromatography over silica gel. And their structures were elucidated through the spectroscopic analysis of MS,NMR and specific rotations. The bioactivities were assayed by paper diffusion and DPPH method. From the fermentation broth of marine-derived Streptomyces sp.MDW-06,five compounds( 1-5) were isolated and identified as streptopentanoic acid( 1),germicidin A( 2),germicidin B( 3),isogermicidin A( 4),isogermicidin B( 5) and oxohygrolidin( 6),respectively. Compound 1 is a new compound. Compound 1 shows DPPH radical scavenging activity with 36. 4% at 100 mg·L~(-1).
