Research on quality standards of standard decoction of Fructus Corni piece.
10.19540/j.cnki.cjcmm.20181221.001
- Author:
Jun-Lin GUO
1
;
Qing SHAO
2
;
Lu-Ming LIU
2
;
Hai-Bin QU
2
;
Xin-Gang DU
3
;
Xing-Chu GONG
4
Author Information
1. Graduate College, Tianjin University of Traditional Chinese Medicine Tianjin 300193, China.
2. Pharmaceutical Informatics Institute, College of Pharmaceutical Science, Zhejiang University Hangzhou 310058, China.
3. Anhui JiuzhouFangyuan Pharmaceutical Co., Ltd. Bozhou, 236800, China.
4. Graduate College, Tianjin University of Traditional Chinese Medicine Tianjin 300193, China Pharmaceutical Informatics Institute, College of Pharmaceutical Science, Zhejiang University Hangzhou 310058, China Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine Nanchang 330004, China.
- Publication Type:Journal Article
- Keywords:
Fructus Corni;
method for standard setting;
quality standard;
standard decoction
- MeSH:
Cornus;
chemistry;
Drugs, Chinese Herbal;
standards;
Fruit;
chemistry;
Quality Control
- From:
China Journal of Chinese Materia Medica
2019;44(11):2260-2265
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to develop the quality standards of Fructus Corni piece standard decoction. Morroniside and loganin were considered as index components. The content determination method of morroniside and loganin were developed. The fingerprint analysis method was also established. The standard decoctions of 15 batches of Fructus Corni pieces from Henan, Zhejiang, and Shaanxi were analyzed. The similarity values of fingerprint were all above 0.99. The transfer rates of morroniside were all higher than 100%. The quality evaluation indices of standard decoction were discussed. The transfer rate of an index component was not easy to be measured accurately and its concept was not rigorous. Therefore, index component yield was suggested as an evaluation index of standard decoction. Two methods for setting quality standards of standard decoctions, which were the ■ method and the ■ method, were compared. It was found that the standard range of ■ method was wider and more suitable for smaller sample size of standard decoction. The quality standards of Fructus Corni standard decoction were as follows, dry matter extraction ratio 37.48%-69.60%; morroniside yield 8.719-16.19 mg·g~(-1) piece; loganin yield 4.342-8.064 mg·g~(-1) piece.
