Multi-target neuroprotective effect of Xixian Tongshuan Preparation against cerebral ischemia injury.
10.19540/j.cnki.cjcmm.20190111.006
- Author:
Yu GU
1
;
Bo-Wen ZHAO
1
;
Xi CHEN
1
;
Yin-Zhen LUO
1
;
Yan-Ling ZHANG
1
Author Information
1. State Laboratory of Traditional Chinese Medicine Information Engineering, State Administration of Traditional Chinese Medicine,School of Chinese Material Medica, Beijing University of Chinese Medicine Beijing 100102, China.
- Publication Type:Journal Article
- Keywords:
Xixian Tongshuan Preparation;
cerebral apoplexy;
molecular docking;
neuroprotection;
virtual screening
- MeSH:
Brain Ischemia;
Cerebral Infarction;
Drugs, Chinese Herbal;
pharmacology;
Humans;
Molecular Docking Simulation;
Neuroprotective Agents;
pharmacology;
Phytochemicals;
pharmacology
- From:
China Journal of Chinese Materia Medica
2019;44(11):2353-2358
- CountryChina
- Language:Chinese
-
Abstract:
In this paper, Xixian Tongshuan Preparation was used as the research object, and all the chemical components of the 13 traditional Chinese medicines were collected. The target finding technique was used to obtain the key targets of the neuroprotective effect of Xixian Tongshuan Preparation, including 5 glutamate receptors, TGFR-1 and VEGFR-2. Molecular docking technology was used to screen out the potential active components of the above targets and to analyze their mechanism of action. It was found that single component, such as neo-complanatoside and neo-carthamin, in Xixian Tongshuan Preparation could simultaneously act on different targets. The chemical constituents in Ligusticum chuanxiong, Angelica sinensis, Carthamus tinctorius, and Panax pseudo-ginseng could simultaneously act on different neuroprotective-related targets, which reflected the application of multi-components to multi-targets. Point and multiple sites played a key role in protecting neurons against cerebral ischemic injury. This study explains the multi-target mechanism of anti-cerebral ischemic injury in neuroprotection at the molecular level, and provides a certain direction for the clinical application and experimental research of Xixian Tongshuan Preparation.
