Curative effect of Wenxin Granule and antiarrhythmic drugs in the treatment of atrial fibrillation:a Meta-analysis.
10.19540/j.cnki.cjcmm.20190308.001
- Author:
Zhao-Bo WANG
1
;
Yu-Juan ZHAO
2
;
Fan-Chao ZHOU
3
;
Yu-Han ZHU
4
;
Lei LIU
4
;
Cong FENG
1
;
Zi-Long CHEN
4
Author Information
1. Heilongjiang University of Chinese Medicine Harbin 150040, China.
2. the Second Hospital of Harbin Harbin 150056, China.
3. Xiangya Second Hospital, Central South University Changsha 410008, China.
4. Beijing University of Chinese Medicine Beijing 100029, China.
- Publication Type:Journal Article
- Keywords:
Meta-analysis;
RCT;
Wenxin Granule;
atrial fibrillation
- MeSH:
Anti-Arrhythmia Agents;
pharmacology;
Atrial Fibrillation;
drug therapy;
Combined Modality Therapy;
Drugs, Chinese Herbal;
pharmacology;
Electric Countershock;
Humans
- From:
China Journal of Chinese Materia Medica
2019;44(11):2379-2389
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the efficiency and safety between Wenxin Granule and antiarrhythmic drugs in the treatment of atrial fibrillation(AF). A total of 8 major electronic databases(CNKI, WanFang, VIP, CBM, Cochrane Library, Web of Science, PubMed, EMbase) were retrieved since the establishment of the database to January 10, 2019. Two reviewers extracted data, and assessed the methodological quality of the included studies. The Meta-analysis was made by RevMan 5.3 software. Finally, 42 studies involving 4 657 patients were included. The results of Meta-analysis showed that compared with antiarrhythmic drug, the combined administration with Wenxin Granule and antiarrhythmic drug had a better clinical efficiency(OR=3.37, 95%CI[2.69,4.22],I~2=0%,P<0.000 01)and efficacy on cardioversion(OR=2.32,95%CI[1.67,3.22],I~2=0%,P<0.000 01), with reduction in P_d(MD=-5.48,95%CI [-7.32,-3.64],I~2=0%,P<0.000 01)and P_(max)(MD=-9.91,95%CI[-12.86,-6.95],I~2=0%,P<0.000 01). The comparison between the combined application with Wenxin Granule and the single application of amiodarone showed a clinical efficiency(OR=2.89,95%CI[1.96,4.26],I~2=44%,P<0.000 01),and efficacy on sinus rhythm maintenance(OR=2.58,95%CI[1.82,3.66],I~2=3%,P<0.000 01). The comparison between the combined application with Wenxin Granule and the single application of amiodarone showed a clinical efficiency(OR=0.88,95%CI[0.53,1.46],I~2=0%,P=0.63). The combined treatment with Wenxin Granule has a better clinical efficiency in AF better than amiodarone, with no evidence for more benefits from the single administration with Wenxin Granules.
