Traffic-related air pollution and allergic rhinitis.
10.13201/j.issn.1001-1781.2018.02.018
- Author:
Guo LIU
;
Shi Xi LIU
- Publication Type:Journal Article
- Keywords:
dendritic cells;
epithelial cells;
particulate matter;
rhinitis, allergic;
traffic-related air pollutants
- MeSH:
Air Pollutants;
toxicity;
Air Pollution;
Humans;
Oxidative Stress;
Rhinitis, Allergic;
etiology;
Vehicle Emissions;
toxicity
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2018;32(2):153-156
- CountryChina
- Language:Chinese
-
Abstract:
Exposure to traffic-related air pollutants(TRAP)has been implicated in airway allergic diseases.Recent findings include epidemiologic and mechanistic studies that shed new light on the impact of TRAP on allergic rhinitis(AR)and the biology underlying this impact.These studies have found that oxidative stress induced by TRAP could affect the axis of epithelial cell-dendritic cell-T cell towards a T-helper 2 immune response,which is the major mechanism between TRAP and AR.Further,epigenetics and microRNA might be involved in this process.Our review will summarize the most recent findings in each of these areas.
