Clinical Significance of Additional Chromosomal 8 Clonal Evolution in CML Progression.
10.7534/j.issn.1009-2137.2018.06.003
- Author:
Ou JI
1
,
2
,
3
;
Guang-Rong ZHU
1
,
4
;
Lin LIN
1
,
4
;
Yu WU
1
,
4
;
Jian-Min JI
1
,
4
;
Hui YU
1
,
4
;
Qun SHEN
1
,
5
Author Information
1. Department of Hematology, Affiliated Hospital
2. Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Pro- vince, China. First Clinical Medical College
3. Nanjing University of Traditional Chinese Medicine, Nanjing 210046, Jiangsu Province, China.
4. Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Pro- vince, China.
5. Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Pro- vince, ChinaE-mail: shenqun1016@163.com.
- Publication Type:Journal Article
- MeSH:
Blast Crisis;
Chromosome Aberrations;
Chromosomes, Human, Pair 8;
Clonal Evolution;
Disease Progression;
Humans;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- From:
Journal of Experimental Hematology
2018;26(6):1598-1603
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To explore the clinical significance of clonal evolution of additional chromosomal 8 in CML progression.
METHODS:An unusual case with the clonal evolution from trisomy 8 to tetrasomy 8 accompanied by 2 time of CML blast crisis (BC) was reported.
RESULTS:This patient suffered from 2 time of CML blast crisis and the additional chromosome 8 aberrations were accompanied. Trisomy 8 and tetrasomy 8 were detected at first CML blast crisis and second CML blast crisis, respectively. After tetrasomy 8 was developed, the c-Myc was over-expressed and the central nervous system leukemia happened in this case. Only high dose Ara-C and MTX regimen could induce remission for a short period.
CONCLUSION:These findings suggested that additional chromosome 8 aberrations are important marker for poor prognosis of CML patients and contribute to a poor prognosis.
