Relationship between Iron Metabolism and Platelet Parameters in Patients with Iron Deficiency Anemia.
10.7534/j.issn.1009-2137.2018.06.026
- Author:
Ding-Ding HAN
1
;
Cong MA
1
;
Ling ZHAO
1
;
Yu-Juan GAO
1
;
Yan-Hua SU
2
Author Information
1. Department of Hematology，The First Affiliated Hospital，Harbin Medical University，Harbin 150000，Heilongjiang Province，China.
2. Department of Hematology，The First Affiliated Hospital，Harbin Medical University，Harbin 150000，Heilongjiang Province，China.E-mail：suyanhua163@163.com.
- Publication Type:Journal Article
- MeSH:
Anemia, Iron-Deficiency;
Erythrocyte Indices;
Ferritins;
Hematocrit;
Hemoglobins;
Humans;
Iron
- From:
Journal of Experimental Hematology
2018;26(6):1738-1741
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between iron metabolism and thrombocytosis.
METHODS:iron metabolism indexes , erythrocyte and platelet parameters of iron deficiency anemia patients with thrombocytosis were collected, the correlation of platelet parameters with iron metabolism indexes and erythrocyte parameters was analysed; the difference in erythrocyte，platelet and iron parameters between severe anemia group (hemoglobin<60 g / L) and mild and moderate anemia group (hemoglobin≥60 g / L) were compared; the changes of platelet count before and after treatment were observed.
RESULTS:There was a significant negative correlation between serum iron and platelet count (r=-0.404,P<0.01).Serum iron negatively correlated with platelet crit(r=-0.288,P<0.05). Transferrin saturation negatively correlated with platelet count and platelet crit(r=-0.353,P<0.01;r=-0.271, P<0.05).Serum ferritin and total iron binding capacity revealed no significant relation with any platelet parameters.Hemoglobin level , hematocrit and mean corpuscular hemoglobin concentration negatively correlated with platelet count(r=-0.239,P<0.05;r=-0.250,P<0.05;r=-0.339,P<0.01).There were differences in iron metabolism indexes and platelet parameters between mild to moderate anemia group and severe anemia group. After treatment, the platelet count decreased or was normal.
CONCLUSION:The important iron metabolism indexes affecting platelet count are serum iron and transferrin saturation,that is,the severer iron deficiency, the higher platelet count.Patients with more severe and hypochronic anemia has higher platelet count.
