Effects of Lidocaine and Propofol on Production of Interleukin (IL)-2, IL-4, and Nitric Oxide in Mice.
10.4097/kjae.2005.49.5.671
- Author:
Su Ryoung CHUNG
1
;
Jun Young KIM
;
Kwang Hyeok KIM
;
Tae Ho CHANG
Author Information
1. Department of Anesthesiology and Pain Medicine, Kosin University School of Medicine, Busan, Korea. JDCOH@ns.kosinmed.or.kr
- Publication Type:Original Article
- Keywords:
IL-2;
IL-4;
lidocaine;
nitric oxide;
propofol
- MeSH:
Anesthesia;
Anesthetics;
Animals;
Humans;
Interleukin-2;
Interleukin-4*;
Interleukins*;
Lidocaine*;
Mice*;
Nitric Oxide*;
Propofol*
- From:Korean Journal of Anesthesiology
2005;49(5):671-678
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The possibility that anesthesia may alter the course of an infection has been under consideration for more a century. Alterations have been found in every component of the immune response during anesthesia and surgery. In this work, we have investigated the effect of lidocaine and propofol on interleukin-2 (IL-2), interleukin-4 (IL-4), and nitric oxide (NO) production in mice. METHODS: The culture supernatants of splenocytes exposed with anesthetics and lipopolysaccharide (LPS), or sera from mice injected with these agents were harvested to assay IL-2, IL-4, and NO. RESULTS: We detected that IL-2 productions of splenocytes culture supernatants and mice sera after exposure with lidocaine or propofol were decreased while IL-4 productions were increased. In addition, NO of mice sera was increased after lidocaine or propofol exposures. CONCLUSIONS: These findings suggest that lidocaine and propofol interfere with IL-2, IL-4, and NO production. This may explain the clinically well-recognized disturbance of human immunity after surgery and anesthesia.
