Association of and Polymorphisms with Risk of Systemic Lupus Erythematosus.

Ke Xue; Wen-quan Niu; Yong Cui

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Association of and Polymorphisms with Risk of Systemic Lupus Erythematosus.

Author: Ke XUE ¹ ; Wen-Quan NIU ² ; Yong CUI ¹
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1. Department of Dermatology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
2. Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
Publication Type:Journal Article
Keywords: HLA-DR15; HLA-DR3; HLA-DRB1; Meta-Analysis; Systemic Lupus Erythematosus
MeSH: Case-Control Studies; Gene Frequency; genetics; Genetic Predisposition to Disease; genetics; HLA-DR Serological Subtypes; genetics; HLA-DR3 Antigen; genetics; HLA-DRB1 Chains; genetics; Haplotypes; genetics; Humans; Lupus Erythematosus, Systemic; Odds Ratio; Polymorphism, Genetic; genetics
From: Chinese Medical Journal 2018;131(23):2844-2851
CountryChina
Language:English
Abstract: Background:Systemic lupus erythematosus (SLE) is an autoimmune disease under genetic control. Growing evidences support the genetic predisposition of HLA-DRB1 gene polymorphisms to SLE, yet the results are not often reproducible. The purpose of this study was to assess the association of two polymorphisms of HLA-DRB1 gene (HLA-DR3 and HLA-DR15) with the risk of SLE via a comprehensive meta-analysis.
Methods:This study complied with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Case-control studies on HLA-DRB1 and SLE were searched from PubMed, Elsevier Science, Springer Link, Medline, and Cochrane Library database as of June 2018. Analysis was based on the random-effects model using STATA software version 14.0.
Results:A total of 23 studies were retained for analysis, including 5261 cases and 9838 controls. Overall analysis revealed that HLA-DR3 and HLA-DR15 polymorphisms were associated with the significant risk of SLE (odds ratio [OR]: 1.60, 95% confidence interval (CI): 1.316-1.934, P = 0.129 and OR: 1.68, 95% CI: 1.334-2.112, P = 0.001, respectively). Subgroup analyses demonstrated that for both HLA-DR3 and HLA-DR15 polymorphisms, ethnicity was a possible source of heterogeneity. Specifically, HLA-DR3 polymorphism was not associated with SLE in White populations (OR: 1.60, 95% CI: 1.320-1.960, P = 0.522) and HLA-DR15 polymorphism in East Asian populations (OR: 1.65, 95% CI: 1.248-2.173, P = 0.001). In addition, source of control was another possible source for both HLA-DR3 and HLA-DR15 polymorphisms, with observable significance for HLA-DR3 in only population-based studies (OR: 1.65, 95% CI: 1.370-1.990, P = 0.244) and for HLA-DR15 in both population-based and hospital-based studies (OR: 1.38, 95% CI: 1.078-1.760, P = 0.123 and OR: 2.08, 95% CI: 1.738-2.490, P = 0.881, respectively).
Conclusions:HLA-DRB1 gene may be a SLE-susceptibility gene, and it shows evident ethnic heterogeneity. Further prospective validations across multiple ethnical groups are warranted.