The Difference of Lymphocyte Subsets Including Regulatory T-Cells in Umbilical Cord Blood between AGA Neonates and SGA Neonates.
10.3349/ymj.2015.56.3.798
- Author:
Sang Hee YOON
1
;
Mina HUR
;
Han Sung HWANG
;
Han Sung KWON
;
In Sook SOHN
Author Information
1. Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea. 19960011@kuh.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Small for gestational age;
cord blood;
regulatory T-cell;
lymphocyte subset
- MeSH:
Biological Markers/metabolism;
Female;
Fetal Blood/*immunology;
Gestational Age;
Humans;
Infant, Newborn/*blood;
Infant, Small for Gestational Age/*blood;
Lymphocyte Count;
T-Lymphocytes, Cytotoxic/metabolism;
T-Lymphocytes, Regulatory/*metabolism
- From:Yonsei Medical Journal
2015;56(3):798-804
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study aimed to compare the regulatory T cells in cord blood of appropriate for gestational age (AGA) neonates with those of small for gestational age (SGA) neonates. MATERIALS AND METHODS: Umbilical cord blood was collected upon labor in 108 healthy full-term (between 37 and 41 gestational weeks) neonates, who were born between November 2010 and April 2012. Among them, 77 samples were obtained from AGA neonates, and 31 samples were obtained from SGA neonates. Regulatory T cells and lymphocyte subsets were determined using a flow cytometer. Student's t-test for independent samples was used to compare differences between AGA and SGA neonates. RESULTS: Regulatory T cells in cord blood were increased in the SGA group compared with normal controls (p=0.041). However, cytotoxic T cells in cord blood were significantly decreased in the SGA group compared with normal controls (p=0.007). CONCLUSION: This is the first study to compare the distribution of lymphocyte subsets including regulatory T cells in cord blood between AGA neonates and SGA neonates.
