Early diagnosis of acute kidney injury in aged patients undergoing percutaneous coronary intervention.
- Author:
Hong-Hua YE
1
;
Gen SHEN
1
;
Qun LUO
2
;
Fang-Fang ZHOU
2
;
Xiao-Ling XIE
1
;
Chun-Yan WANG
1
;
Li-Na HAN
2
Author Information
- Publication Type:Journal Article
- Keywords: Liver-type fatty acid-binding protein; Neutrophil gelatinase-associated lipocalin; Kidney injury molecule-1; Percutaneous coronary intervention; Acute kidney injury
- MeSH: Acute Kidney Injury; diagnosis; urine; Aged; Aged, 80 and over; Early Diagnosis; Fatty Acid-Binding Proteins; urine; Female; Hepatitis A Virus Cellular Receptor 1; analysis; Humans; Lipocalin-2; urine; Male; Percutaneous Coronary Intervention; adverse effects
- From: Journal of Zhejiang University. Science. B 2018;19(5):342-348
- CountryChina
- Language:English
- Abstract: In aged patients, acute kidney injury (AKI) is a common clinical complication after percutaneous coronary intervention (PCI), highlighting the need for timely and certain diagnosis of this disease. A single centre, nested case-control study was conducted, which assessed the usefulness of urinary liver-type fatty acid-binding protein (uL-FABP), neutrophil gelatinase-associated lipocalin (uNGAL), and kidney injury molecule-1 (uKIM-1) for early detection of AKI. One hundred and thirty-two patients at or over 60 years old undergoing PCI were included. Serum creatinine (SCr) was measured before PCI, 24 and 48 h after PCI; uL-FABP, uNGAL, and uKIM-1 were measured before PCI, 6, 24, and 48 h after PCI. We identified 16 AKI patients and selected 32 control patients matched by admission time (<1 week), age (±5 years), and gender. In the receiver operating characteristic (ROC) curve analysis, the areas under the curve (AUCs) for the relative measurements of uL-FABP, uNGAL, and uKIM-1 were 0.809, 0.867, and 0.512 at 6 h after PCI, and 0.888, 0.840, and 0.676 at 24 h after PCI, respectively. AUC for the combination of uL-FABP and uNGAL was 0.899 at 6 h after PCI, and 0.917 at 24 h after PCI. Thus, measurement of uL-FABP and uNGAL levels at 6 and 24 h after PCI may be useful in detecting AKI in aged patients. Measurement of uKIM-1 levels provides inferior predictive power for early diagnosis of AKI.
