Comparison of reference values for immune recovery between event-free patients receiving haploidentical allografts and those receiving human leukocyte antigen-matched sibling donor allografts.
10.1007/s11684-017-0548-1
- Author:
Xuying PEI
1
;
Xiangyu ZHAO
1
;
Yu WANG
1
;
Lanping XU
1
;
Xiaohui ZHANG
1
;
Kaiyan LIU
1
;
Yingjun CHANG
2
;
Xiaojun HUANG
3
Author Information
1. Peking University People's Hospital & Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
2. Peking University People's Hospital & Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China. rmcyj@bjmu.edu.cn.
3. Peking University People's Hospital & Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China. xjhrm@medmail.com.cn.
- Publication Type:Journal Article
- Keywords:
event-free patients;
hematopoietic stem cell transplantation;
immune reconstitution;
reference range
- MeSH:
Adolescent;
Adult;
Child;
Child, Preschool;
China;
Disease-Free Survival;
Female;
Graft vs Host Disease;
immunology;
mortality;
HLA Antigens;
immunology;
Hematopoietic Stem Cell Transplantation;
Humans;
Immune Reconstitution;
Male;
Middle Aged;
Reference Values;
Siblings;
T-Lymphocytes;
immunology;
Tissue Donors;
Transplantation, Homologous;
Young Adult
- From:
Frontiers of Medicine
2018;12(2):153-163
- CountryChina
- Language:English
-
Abstract:
To establish optimal reference values for recovered immune cell subsets, we prospectively investigated post-transplant immune reconstitution (IR) in 144 patients who received allogeneic stem cell transplantation (allo- SCT) and without showing any of the following events: poor graft function, grades II‒IV acute graft-versus-host disease (GVHD), serious chronic GVHD, serious bacterial infection, invasive fungal infection, or relapse or death in the first year after transplantation. IR was rapid in monocytes, intermediate in lymphocytes, CD3 Tcells, CD8 T cells, and CD19 B cells, and very slow in CD4 T cells in the entire patient cohort. Immune recovery was generally faster under HLA-matched sibling donor transplantation than under haploidentical transplantation. Results suggest that patients with an IR comparable to the reference values display superior survival, and the levels of recovery in immune cells need not reach those in healthy donor in the first year after transplantation.We suggest that data from this recipient cohort should be used as reference values for post-transplant immune cell counts in patients receiving HSCT.
