A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation.
10.1007/s11684-017-0558-z
- Author:
Xiaofeng SHI
1
;
Rong BA
1
;
Haiyan YOU
1
;
Qian JIANG
1
;
Jiansong HUANG
2
;
Jianhua MAO
3
;
Lanxiu HAN
1
;
Shuo ZHANG
1
;
Qin ZHUANG
1
;
Xianqiu YU
1
;
Lixia WANG
1
;
Yun WANG
1
;
Dongya LI
1
;
Wei ZHU
4
;
Yong ZHANG
5
;
Yan ZHU
6
;
Xiaodong XI
7
Author Information
1. Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
2. Institute of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
3. State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Collaborative Innovation Center of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
4. School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
5. Blood Cell Development and Function Program Fox Chase Cancer Center, 333 Cottman Avenue, Room 364, Philadelphia, PA, 19111-2497, USA.
6. Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China. zhuyan19591959@163.com.
7. State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Collaborative Innovation Center of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. xixiaodong@shsmu.edu.cn.
- Publication Type:Case Reports
- Keywords:
chromosome translocation;
splenic lymphoma with villous lymphocytes;
splenic marginal zone lymphoma;
transformation
- MeSH:
Aged;
B-Lymphocytes;
pathology;
Female;
Humans;
Immunophenotyping;
Lymphoproliferative Disorders;
genetics;
pathology;
Translocation, Genetic
- From:
Frontiers of Medicine
2018;12(3):324-329
- CountryChina
- Language:English
-
Abstract:
Splenic lymphoma with villous lymphocytes (SLVL) or splenic marginal zone lymphoma with circulating villous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer. At present, only one case of SLVL with t(8;14)(q24;q32) translocation has been reported. In this study, we report a case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) chromosome translocation that we inclined to SLVL with a prolymphocytic transformation. A 73-year-old female showed marked hepatosplenomegaly and high lymphocytosis (lymphocytes > 200 × 10/L). The abnormal lymphocytes had short coarse villi and round nuclei with prominent nucleoli. The immunophenotypes showed CD19, CD20, HLA-DR, CD22, CD5, Kappa, CD25, CD71, Lambda, CD7, CD10, CD23, CD34, CD33, CD13, CD14, CD117, CD64, CD103, and CD11c. The karyotype showed complex abnormality: 46XX,+ 3,-10, t(8;14)(q24; q32)[11]/46XX[9]. The cytoplasmic projection, immunological characteristics, and trisomy 3 chromosome abnormality supported the diagnosis of SLVL. However, the presence of prominent nucleoli and high lymphocytosis suggested prolymphocytic transformation, probably as a result of t(8,14) chromosome translocation. In this report, we described an unusual case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation, which could provide help in the diagnosis and differential diagnosis of B-lymphocytic proliferative diseases.
