Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely and successfully become pregnant-a Chinese retrospective cohort study among 148 cases.
10.1007/s11684-017-0554-3
- Author:
Bin YANG
1
;
Yan YU
2
;
Jing CHEN
1
;
Yan ZHANG
1
;
Ye YIN
1
;
Nan YU
1
;
Ge CHEN
1
;
Shifei ZHU
1
;
Haiyan HUANG
3
;
Yongqun YUAN
1
;
Jihui AI
1
;
Xinyu WANG
4
;
Kezhen LI
5
Author Information
1. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China.
2. Department of Gynecologic Oncology, Women's Hospital, Zhejiang University, Hangzhou, 310006, China.
3. Department of Gynecologic Oncology, Women's Hospital, Zhongxiang, 431900, China.
4. Department of Gynecologic Oncology, Women's Hospital, Zhejiang University, Hangzhou, 310006, China. wangxy@zju.edu.cn.
5. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China. tjkeke@126.com.
- Publication Type:Journal Article
- Keywords:
fertility;
fertility-sparing surgery;
malignant germ cell tumors;
ovarian sex cord-stromal tumors;
prognosis
- MeSH:
Adolescent;
Adult;
Chemotherapy, Adjuvant;
adverse effects;
Child;
China;
Female;
Humans;
Infertility, Female;
etiology;
prevention & control;
Neoplasm Staging;
Organ Sparing Treatments;
Ovarian Neoplasms;
drug therapy;
surgery;
Pregnancy;
Pregnancy Rate;
Prognosis;
Retrospective Studies;
Survival Analysis;
Young Adult
- From:
Frontiers of Medicine
2018;12(5):509-517
- CountryChina
- Language:English
-
Abstract:
This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000 and August 31, 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overall survival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P = 0.023), whereas histology significantly influenced OS. Cox regression analysis suggested that only histology was associated with PFS and OS (P < 0.05). Among the 129 women who completed adjuvant chemotherapy (ACT), none developed amenorrhea. Among the 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestations including 35 live births without birth defects. Non-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy. Histology might be the only independent prognostic factor for PFS and OS. FSS followed by ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase the PFS or OS. Use of gonadotropin-releasing hormone agonist was not beneficial for fertility.
