Cyclospora cayetanensis infections among diarrheal outpatients in Shanghai: a retrospective case study.
10.1007/s11684-018-0614-3
- Author:
Yanyan JIANG
1
,
2
;
Zhongying YUAN
1
,
2
;
Guoqing ZANG
3
;
Dan LI
3
;
Ying WANG
1
,
2
;
Yi ZHANG
3
;
Hua LIU
1
,
2
;
Jianping CAO
1
,
4
;
Yujuan SHEN
1
,
5
Author Information
1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention
2. Key Laboratory of Parasite and Vector Biology, Ministry of Health, China, WHO Collaborating Center for Tropical Diseases, Shanghai, 200025, China.
3. Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
4. Key Laboratory of Parasite and Vector Biology, Ministry of Health, China, WHO Collaborating Center for Tropical Diseases, Shanghai, 200025, China. caojpcdc@163.com.
5. Key Laboratory of Parasite and Vector Biology, Ministry of Health, China, WHO Collaborating Center for Tropical Diseases, Shanghai, 200025, China. amyshyj12@163.com.
- Publication Type:Journal Article
- Keywords:
18S rRNA gene;
Cyclospora cayetanensis;
outpatients with diarrhea;
stool specimens
- MeSH:
Adolescent;
Adult;
China;
epidemiology;
Cyclospora;
genetics;
isolation & purification;
Cyclosporiasis;
epidemiology;
Diarrhea;
etiology;
parasitology;
Feces;
parasitology;
Female;
Humans;
Male;
Middle Aged;
Outpatients;
Phylogeny;
Polymerase Chain Reaction;
RNA, Ribosomal, 18S;
analysis;
Retrospective Studies;
Young Adult
- From:
Frontiers of Medicine
2018;12(1):98-103
- CountryChina
- Language:English
-
Abstract:
Cyclospora cayetanensis is a foodborne and waterborne pathogen that causes endemic and epidemic human diarrhea worldwide. A few epidemiological studies regarding C. cayetanensis infections in China have been conducted. During 2013, a total of 291 stool specimens were collected from patients with diarrhea at a hospital in urban Shanghai. C. cayetanensis was not detected in any of the stool specimens by traditional microscopy, whereas five stool specimens (1.72%, 5/291) were positive by PCR. These positive cases confirmed by molecular technology were all in the adult group (mean age 27.8 years; 2.94%, 5/170) with watery diarrhea. Marked infection occurred in the rainy season of May and July. Sequence and phylogenetic analyses of the partial 18S rRNA genes of C. cayetanensis isolated showed intra-species diversity of this parasite. This study showed, for the first time, that C. cayetanensis is a pathogen in outpatients with diarrhea in Shanghai, albeit at a low level. However, the transmission dynamics of this parasite in these patients remain uncertain.
