γδ T cells in liver diseases.
10.1007/s11684-017-0584-x
- Author:
Xuefu WANG
1
;
Zhigang TIAN
2
Author Information
1. School of Pharmacy, Anhui Medical University, Hefei, 230032, China. wangxuefu@ustc.edu.cn.
2. Institute of Immunology and CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, 230027, China.
- Publication Type:Journal Article
- Keywords:
autoimmune hepatitis;
liver cancer;
liver fibrosis and cirrhosis;
liver infection;
liver regeneration;
non-alcoholic fatty liver disease;
γδT cells
- MeSH:
Animals;
Cytokines;
immunology;
Humans;
Liver Diseases;
immunology;
Liver Regeneration;
immunology;
Mice;
T-Lymphocytes, Regulatory;
immunology
- From:
Frontiers of Medicine
2018;12(3):262-268
- CountryChina
- Language:English
-
Abstract:
γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration. In this study, we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases. We believe that determining the properties and functions of γδ T cells in liver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.
