Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas.
10.1007/s11684-017-0572-1
- Author:
Lan YU
1
;
Xun TIAN
1
;
Chun GAO
1
;
Ping WU
1
;
Liming WANG
1
;
Bei FENG
1
;
Xiaomin LI
1
;
Hui WANG
1
;
Ding MA
2
;
Zheng HU
3
Author Information
1. Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
2. Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. dma@tjh.tjmu.edu.cn.
3. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. huzheng1998@163.com.
- Publication Type:Journal Article
- Keywords:
delivery method;
genome-editing tools;
off-target effect;
tumorigenic virus;
virus-related carcinoma
- MeSH:
Antiviral Agents;
therapeutic use;
CRISPR-Cas Systems;
Carcinoma;
genetics;
therapy;
virology;
Gene Editing;
Genetic Predisposition to Disease;
Genetic Therapy;
methods;
Humans;
Tumor Virus Infections;
complications
- From:Frontiers of Medicine
2018;12(5):497-508
- CountryChina
- Language:English
-
Abstract:
Viral infections cause at least 10%-15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virus-related carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.
