Research progress on the relationship between periodontal disease and common malignancies.

Author: Yu HAO ¹ ; Xian PENG ¹ ; Xue-Dong ZHOU ¹ ; Lei CHENG ¹
Author Information

1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
Keywords: breast cancer; gastrointestinal malignancies; lung cancer; periodontal disease
MeSH: Humans; Microbiota; Neoplasms; complications; Periodontal Diseases; complications; Periodontium; Research
From: West China Journal of Stomatology 2019;37(3):320-324
CountryChina
Language:Chinese
Abstract: Periodontal disease is a common oral disease that can cause irreversible damage of periodontal support tissue. Studies on the relationship between periodontal disease and malignancies have also increased. In this review, the relationship between periodontal disease and gastrointestinal malignancies (e.g., stomach cancer, colorectal cancer, and pancreatic cancer), lung cancer, and breast cancer are discussed. The related mechanisms are summarized in terms of four aspects, namely, immu-nity, inflammation, gene, and microbiota and its products, to provide novel methods for the prevention and early diagnosis of malignancies.