Effects of platelet-derived growth factor on nerve regeneration around implant in rats.

Yan-ying Wang; Ping Gong; Jian Zhang

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Effects of platelet-derived growth factor on nerve regeneration around implant in rats.

Author: Yan-Ying WANG ^{1
,

2} ; Ping GONG ³ ; Jian ZHANG ^{1
,

2}
Author Information

1. Dept. of Implantology, Tianjin Stomatological Hospital
2. Hospital of Stomatology, Nankai University, Tianjin 300041, China.
3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
Keywords: implant; nerve fiber; nerve regeneration; osseoperception; platelet-derived growth factor
MeSH: Animals; Dental Implants; Nerve Fibers; Nerve Regeneration; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley
From: West China Journal of Stomatology 2019;37(4):350-354
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To investigate the effect of platelet-derived growth factor (PDGF) on nerve regeneration in peri-implant tissues.
METHODS:SD rats with implants in their femurs were injected with PDGF solution. The effects of PDGF on nerve regeneration in peri-implant tissues were analyzed by immunohistochemical staining.
RESULTS:PDGF increased the number of nerve fibers in peri-implant tissues at early stage. PDGF had no significant effect on the number of nerve fibers in peri-implant tissues at late stage. Moreover, these nerves had a typical structure of peripheral nerve fibers.
CONCLUSIONS:PDGF can promote nerve regeneration in peri-implant tissues at early stage. This study provided a certain experimental basis for the clinical application of PDGF to promote nerve regeneration and further improve the sensory function of the implant.