Effects of concentrated growth factors on relieving postoperative reaction of guided bone regeneration in the esthetic zone.

Tian-Tian YU; Jin LIU; Jun-Jing YIN; Xiang-Na XU; Sheng-Jie YAN; Jing LAN

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Effects of concentrated growth factors on relieving postoperative reaction of guided bone regeneration in the esthetic zone.

Author: Tian-Tian YU ^{1
,

2
,

3} ; Jin LIU ^{1
,

4} ; Jun-Jing YIN ^{1
,

2
,

5} ; Xiang-Na XU ^{1
,

6} ; Sheng-Jie YAN ^{1
,

6} ; Jing LAN ^{1
,

6}
Author Information

1. Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China
2. Dept. of Implantology, School & Hospital of Stomatology, Shandong University, Jinan 250012, China
3. Dept. of Implantology, Yantai Stomatology Hospital, Yantai 264008, China.
4. Dept. of Prosthodontics, School & Hospital of Stomatology, Shandong University, Jinan 250012, China.
5. Dept. of Oral and Maxillofacial Surgery, Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, China.
6. Dept. of Implantology, School & Hospital of Stomatology, Shandong University, Jinan 250012, China.
Publication Type:Journal Article
Keywords: concentrated growth factors; guided bone regeneration; postoperative reaction
MeSH: Bone Regeneration; Dental Implants; Esthetics; Humans; Intercellular Signaling Peptides and Proteins; Maxilla; Pain, Postoperative
From: West China Journal of Stomatology 2019;37(4):398-402
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To explore the effect of concentrated growth factors (CGF) on postoperative pain and swelling in patients with complex dental implants.
METHODS:A total of 28 patients with single maxillary anterior teeth loss and labial orbital bone defect were recruited randomly and divided into two groups. Each group included 14 patients. The experimental group was applied with CGF membrane to guide bone regeneration, whereas the control group was treated with collagen membrane to guide bone regeneration. The postoperative pain degree and swelling degree were compared, and data were analyzed with SPSS 23.0 software. Postoperative pain was measured by visual analogue scale (VAS), and the degree of swelling was divided into four grades according to swelling range.
RESULTS:VAS scores of patients in experimental and control groups reached 35.1±22.5 and 47.0±20.3, respectively. The duration of postoperative pain in experimental and control groups totaled (2.1±1.5) and (2.8±1.0) days, respectively. No statistically significant difference was observed between the two groups (P>0.05). Percentages of non-swelling, mild swelling, moderate swelling, and severe swelling in experimental group reached 21.4%, 57.1%, 21.4%, and 0, respectively, and those in control group were 7.1%, 35.7%, 35.7%, and 21.4%. Swelling duration reached (2.4±1.4) and (4.2±2.2) days in the experimental and control groups, respectively. A statistically significant difference was observed in the swelling degree of experimental and control groups (P<0.05).
CONCLUSIONS:The use of CGF can significantly reduce the degree of postoperative swelling and shorten swelling time but cause no significant effect on pain.