Potential application of human microbiomes in the diagnosis and treatment of type 2 diabetes mellitus.

Author: Yun-Kun LIU ¹ ; Xin XU ¹ ; Xue-Dong ZHOU ¹
Author Information

1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
Keywords: gut microbiome; oral microbiome; precision medicine; type 2 diabetes mellitus
MeSH: Diabetes Mellitus, Type 2; Gastrointestinal Microbiome; Humans; Microbiota
From: West China Journal of Stomatology 2019;37(5):556-562
CountryChina
Language:Chinese
Abstract: Human microbiome refers to the total microorganism genetic information of human body surface and internal, which is closely related to human health and disease. Oral and gut microbiomes are the most diverse microbial communities, which can interact and play a role in the development of the disease, and can reflect the health and disease state in real time. Type 2 diabetes mellitus is a metabolic disorder caused by both genetic and environmental factors. Recent research has shown a link between microbes and diabetes. This article reviewed the latest research on the changes of oral and gut microbiomes in type 2 diabetes mellitus patients, which expects to provide a reference for exploring the development of the disease model for prediction, diagnosis and prognosis of type 2 diabetes mellitus based on human microbiome characteristics.