Regulatory effect of Vav1 on T cells and its relation to clinical diseases.
- Author:
Yuchuan ZHANG
1
;
Wei CHEN
1
Author Information
1. Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Adaptor Proteins, Signal Transducing;
Animals;
Autoimmune Diseases;
genetics;
physiopathology;
Humans;
Neoplasms;
genetics;
physiopathology;
Proto-Oncogene Proteins c-vav;
chemistry;
immunology;
metabolism;
T-Lymphocytes
- From:
Journal of Zhejiang University. Medical sciences
2018;47(1):75-81
- CountryChina
- Language:Chinese
-
Abstract:
Vav1, as a key downstream signaling molecule of T cell receptor, includes a catalytic core DH-PH-ZF domain with the function as guanine nucleotide exchange factor (GEF), and a SH3-SH2-SH3 domain with the function as adaptor protein. These two structures of Vav1 play different roles in the development, activation, proliferation and function of T cells, and thereby exert the different regulatory effect on the occurrence and development of autoimmune disease, graft rejection, cancer and other clinical conditions, implicating that Vav1 might be a potential therapeutic target for these diseases. This paper reviews the role of Vav1 in T cells and the occurrence of related diseases.
