Research progress on genotyping of .
- Author:
Jiajing WANG
1
;
Haiying GU
1
Author Information
1. Medical School of Ningbo University, Ningbo 315211, Zhejiang Province, China.
- Publication Type:Journal Article
- MeSH:
Amplified Fragment Length Polymorphism Analysis;
Genotype;
Helicobacter Infections;
microbiology;
pathology;
Helicobacter pylori;
genetics;
Humans;
Polymerase Chain Reaction;
Research
- From:
Journal of Zhejiang University. Medical sciences
2018;47(1):97-103
- CountryChina
- Language:Chinese
-
Abstract:
(Hp) is widely disseminated in human, and Hp infection causes various gastrointestinal diseases, including gastric cancer. Different genotypes of Hp may cause different diseases, so the genotyping is important for clinical and basic research of Hp. This article introduces the methods for Hp genotyping, including multilocus sequence typing, pulsed-field gel electrophoresis, random amplified polymorphic DNA, amplified fragment length polymorphism, and whole-genome sequencing. By reviewing the application of these techniques in Hp genotyping and comparing their advantages and disadvantages, the article provides a theoretical basis for research into the pathogenesis, antibiotic resistance, and epidemiology of Hp infection.
