Associations among PRDM16 polymorphisms, environmental exposure factors during mother's pregnancy, and nonsyndromic cleft lip with or without cleft palate.
- Author:
Bin YIN
1
;
Bing SHI
1
;
Zhong-Lin JIA
1
Author Information
- Publication Type:Journal Article
- Keywords: PRDM16 gene; linkage disequilibrium; nonsyndromic cleft lip with or without cleft palate; single nucleotide polymorphism; transmission disequilibrium test
- MeSH: Alcohol Drinking; adverse effects; Case-Control Studies; Cleft Lip; genetics; Cleft Palate; genetics; DNA-Binding Proteins; Environmental Exposure; Female; Genotype; Humans; Infant, Newborn; Mothers; Polymorphism, Single Nucleotide; Pregnancy; Smoking; adverse effects; Transcription Factors
- From: West China Journal of Stomatology 2018;36(5):503-507
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:We aimed to study the association between rs7525173, rs2236518, rs2493264 single nucleotide polymorphism (SNP) in the PRDM16 gene, smoking, alcohol exposures, and nonsyndromic cleft lip with or without cleft palate (NSCL/P).
METHODS:A total of 157 case-parent trios were selected, and SNPs were genotyped by using ligase detection reaction (LDR) and direct sequencing methods. Transmission disequilibrium test (TDT) and linkage disequilibrium (LD) tests were con-ducted to analyze the data. A total of 1 710 patients with orofacial clefts and 956 healthy newborns were enrolled in the epidemiological survey. The smoking and drinking exposures of parents during early pregnancy were analyzed.
RESULTS:The C allele at rs2236518 was over-transmitted for NSCPO (P<0.05). Statistical differences were observed among three factors, namely, maternal smoking, maternal passive smoking, and maternal drinking (P<0.05).
CONCLUSIONS:The rs2236518 at PRDM16 gene, maternal smoking, maternal passive smoking, and maternal drinking were closely related to the occurrence of NSCL/P.
