Impacts of periodontitis on visceral organ weight and weight percentage in obese mice.

Ting YU; Li Zhao; Jin-cai Zhang; Dong-ying Xuan

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Impacts of periodontitis on visceral organ weight and weight percentage in obese mice.

Author: Ting YU ¹ ; Li ZHAO ² ; Jin-Cai ZHANG ³ ; Dong-Ying XUAN ⁴
Author Information

1. Dept. of Periodontology, Stomatology Hospital of Guangzhou Medical University, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Guangzhou 510140, China.
2. Dept. of Prosthodontics, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China.
3. Savaid Medical School, University of Chinese Academy of Sciences, Beijing100049, China.
4. Dept. of Periodontology, Hangzhou Dental Hospital, Savaid Medical School, University of Chinese Academy of Sciences, Hangzhou 310006, China.
Publication Type:Journal Article
Keywords: obesity; pathology; periodontitis; spleen; viscera
MeSH: Animals; Diet, High-Fat; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; complications; Organ Size; Periodontitis; complications
From: West China Journal of Stomatology 2018;36(5):514-520
CountryChina
Language:Chinese
Abstract: OBJECTIVE:This study aimed to explore the impacts of periodontitis on the visceral weight and weight percentage of obese animal models.
METHODS:A total of 64 C57BL/6J mice were divided into the following diet groups: high-fat diet (HFD) group (n=36), which was fed with high-fat diet to induce obesity, and low-fat diet (LFD) group (n=28), which was fed with low-fat diet as the control. After 16 weeks on diet, each diet group was divided into periodontitis (P) and control (C) groups. The P groups were induced for periodontitis by ligation with Porphyromonas gingivalis-adhered silk for 5 or 10 days, and the C groups were sham-ligated as the control. Visceral organs were resected and weighed. The organ weight percentage was calculated.
RESULTS:Compared with the LFD group, the HFD group significantly upregulated the weight and weight percentage of visceral adipose tissue and spleen (P<0.05), upregulated the weight of liver and kidney (P<0.05), and downregulated the weight percentage of liver and kidney (P<0.01). In the HFD group, the weight and weight percentage of spleen were downregulated in the P group (P<0.05), but were upregulated in the 10-day group compared with the 5-day group (P<0.05).
CONCLUSIONS:Periodontitis can affect the general morphology of the viscera (especially spleen) in obese animal models. Pathological indications in terms of immunometabolism might be present in the correlation between obesity and periodontitis.