Selective laser sintering and performances of porous titanium implants.

Ting WEI; Xin-Wei ZHANG; Hui-Qiang SUN; Meng-Yun MAO

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Selective laser sintering and performances of porous titanium implants.

Author: Ting WEI ¹ ; Xin-Wei ZHANG ² ; Hui-Qiang SUN ³ ; Meng-Yun MAO ⁴
Author Information

1. Dept. of Prosthodontics, College of Stomatology, Shandong University, Jinan 250012, China.
2. Dept. of Stomatology, The Second Hospital of Anhui Medical University, Hefei 230601, China.
3. Shandong Provincial Key Laboratory of Oral Biomedicine, Jinan 250012, China.
4. Dept. of Prosthodontics, Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Publication Type:Journal Article
Keywords: biocompatibility; chitosan/hydroxyapatite composite coating; selective laser sintering; titanium implant
MeSH: Animals; Durapatite; Lasers; Materials Testing; Microscopy, Electron, Scanning; Osseointegration; Porosity; Prostheses and Implants; Rabbits; Surface Properties; Titanium
From: West China Journal of Stomatology 2018;36(5):532-538
CountryChina
Language:Chinese
Abstract: OBJECTIVE:This work aims to analyze the mechanical properties and biocompatibility of porous titanium (Ti) implants fabricated by selective laser sintering (SLS) and investigate the promotion of osseointegration by porous titanium implant combined with chitosan (CS)/hydroxyapatite(HA) composite coating.
METHODS:Ti6Al4V specimens were prepared, and CS/HA composite coating was fabricated on the surface of a portion of the specimens. The mechanical properties of the samples were observed by scanning electron microscope. MC3T3-E1 cells were cultured in vitro, and their biological properties in vitro were analyzed using live and dead viability cell staining method, methyl thiazolyl tetrazolium (MTT) staining, and alkaline phosphatase (ALP) level detection. The thread implant specimens were implanted in the femoral condyle of rabbits, and biological performance was evaluated in vivo.
RESULTS:Quasi-elastic gradient of porous specimens decreased with increasing porosity, and the quasi-elastic gradient were close to cortical and cancellous bone when the porosities were 30% and 70%. The specimens showed good biocompatibility. Combined with CS/HA coating, the implants promoted the proliferation and differentiation of MC3T3-E1 cells and facilitated the entry of bone tissue into pores and good osteogenesis.
CONCLUSIONS:The porous titanium implant exhibited favorable mechanical properties and biocompatibility. Combined with CS/HA coating, the implant exhibited bone inducibility, which leads to stable osteogenesis.