Invasion and metastasis mechanism of human papillomavirus in head and neck squamous cell carcinomas.

Guang-xue Cui; Xiao-lei Gao; Xin-hua Liang

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Invasion and metastasis mechanism of human papillomavirus in head and neck squamous cell carcinomas.

Author: Guang-Xue CUI ¹ ; Xiao-Lei GAO ² ; Xin-Hua LIANG ²
Author Information

1. Dept. of Oral and Maxillofacial Surgery, Affiliated Hospital of Chifeng University, Chifeng 024000, China.
2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
Keywords: head and neck squamous cell carcinomas; human papillomavirus; invasion and metastasis
MeSH: Head and Neck Neoplasms; pathology; virology; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Papillomaviridae; Papillomavirus Infections; Squamous Cell Carcinoma of Head and Neck; pathology; virology
From: West China Journal of Stomatology 2018;36(5):544-551
CountryChina
Language:Chinese
Abstract: Human papillomavirus (HPV) is a major causative agent of head and neck squamous cell carcinomas (HNSCC). Over the past several decades, an increasing number of studies established the strong association of HPV with the invasion and metastasis of HNSCC. In the present study, we reviewed the gene mutations in HPV-associated HNSCC and the unique mechanism of E6- and E7-mediated carcinogenesis via interactions with an array of cellular elements. We further discussed the progress in the mechanisms of invasion and metastasis; these mechanisms include non-coding RNAs, deregulating cellular energetics, tumor microenvironment, cancer stem cells, angiogenesis, and lymphangiogenesis.