Relationship between thrombospondin-1 and the occurrence and development of oral and maxillofacial malignancy.

Author: Xue-Qin ZHOU ^{1
,

2} ; Jun REN ^{1
,

2} ; Sen YANG ^{1
,

2}
Author Information

1. Graduate School, Zunyi Medical University, Zunyi 563000, China
2. Dept. of Oral and Maxillofacial Surgery, Suining Central Hospital, Suining 629000, China.
Publication Type:Journal Article
Keywords: oral and maxillofacial malignancy; solid tumor; thrombospondin-1; vascular suppression
MeSH: Humans; Neoplasms; Neovascularization, Pathologic; Thrombospondin 1
From: West China Journal of Stomatology 2018;36(6):686-690
CountryChina
Language:Chinese
Abstract: Thrombospondin-1 (TSP-1) is widely distributed in human tissues and is important in inhibiting angiogenesis.It also occupies an indispensable position in the formation, growth, differentiation, and metastasis of tumors in different tissues.TSP-1 plays an important role in the occurrence and development of various types of tumors. The inhibitory effect of TSP-1 on the angiogenesis and tumor development of oral and maxillofacial malignant tumors has been demonstrated in recent years. This paper reviews the findings and progress of TSP-1 research involving all kinds of tumors as well as oral and maxillofacial malignancies.