Analysis of the First Diagnosis Symptom and Its Influencing Factors in 500 Patients with Lung Cancer.
10.3779/j.issn.1009-3419.2018.05.09
- Author:
Xin ZHANG
1
;
Puyuan XING
1
;
Xuezhi HAO
1
;
Junling LI
1
Author Information
1. National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,
Beijing 100021, China.
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Influencing factors;
Lung neoplasms;
Symptom;
Treatment
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Anaplastic Lymphoma Kinase;
China;
ErbB Receptors;
genetics;
metabolism;
Female;
Humans;
Lung Neoplasms;
diagnosis;
genetics;
metabolism;
pathology;
Male;
Middle Aged;
Mutation;
Receptor Protein-Tyrosine Kinases;
genetics;
metabolism;
Retrospective Studies;
Smokers;
statistics & numerical data
- From:
Chinese Journal of Lung Cancer
2018;21(5):408-412
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:As the morbidity and mortality in lung cancer keep raising, we are here to discuss the effect of clinical features especially the initial symptomon on diagnosis and follow-up treatment of newly diagnosed lung cancer patients.
METHODS:The clinical features of the 500 patients with lung cancer in our hospital from March, 2017 to May, 2017 were analyzed retrospectively, including the initial symptom, stage, biomarkers, pathology, etc. RESULTS: There were 266 famle (53.3%), 372 adenocarcinoma (74.4%), 285 smokers (58%), status score of most patients (98.2%) was 0-1. 58.2% (n=291) of all the patients got biomarkers test, of which epidermal growth factor receptor (EGFR) mutations was 61.2%(178/291), anaplasticlymphoma kinase (ALK) fusion gene positive was 4.1% (12/291). Smoking status, initial symptom, pathological typing, TNM staging and EGFR mutation were the main factors affecting follow-up treatment.
CONCLUSIONS:Patients with typical symptoms have shorter diagnosis time. Smoking status, lung cancer-related symptoms, pathology, TNM staging and EGFR mutation status are the main factors that affect the follow-up treatment.
