Expression and Clinical Significance of LC-3 and P62
in Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2018.06.04
- Author:
Cong WANG
1
;
Yongwen LI
2
;
Ying LI
2
;
Hao GONG
1
;
Hongbing ZHANG
1
;
Yin YUAN
1
;
Weiting LI
1
;
Hongyu LIU
2
;
Jun CHEN
1
Author Information
1. Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
2. Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
- Publication Type:Journal Article
- Keywords:
Autophagy;
Immunohistochemistry;
LC-3;
Non-small cell lung cancer;
P62
- MeSH:
Carcinoma, Non-Small-Cell Lung;
diagnosis;
metabolism;
Female;
Gene Expression Regulation, Neoplastic;
Humans;
Kaplan-Meier Estimate;
Lung Neoplasms;
diagnosis;
metabolism;
Male;
Microtubule-Associated Proteins;
metabolism;
Middle Aged;
Prognosis;
Proto-Oncogene Proteins c-myc;
metabolism
- From:
Chinese Journal of Lung Cancer
2018;21(6):445-450
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:LC-3 and P62, two of important autophagy-related proteins, were reported highly expressed in many kinds of human malignancies and associated with outcomes of the patients. The purpose of this study was to investigate the expression status of LC-3 and P62 in non-small cell lung cancer patients and define the clinical-pathologic features.
METHODS:66 cases of non-small cell lung cancer patients were employed. The expression of LC-3 and P62 were detected by immunohistochemistry.
RESULTS:LC-3 was positive stained in 27 out of 66 cases (40.9%) and P62 was positive stained in 43 out of 66 cases (65.2%). LC-3 positive staining was more frequently in squamous cell carcinoma patients (P<0.05); while P62 positive staining was more frequently in late-stage adenocarcinoma patients with metastasis (P<0.05). There was a significant negative correlation between LC-3 and P62 expressions in non-small cell lung cancer tissues (rs=-0.065, P<0.001). Kaplan-Meier analysis showed that patients with positive LC-3 expression had favorable clinical outcomes compared with the patients with negative LC-3 expression (P<0.05).
CONCLUSIONS:LC-3 and P62 showed abnormal expression in non-small cell lung cancer tissues, suggesting that autophagy is involved in the occurrence and development of NSCLC.
