Risk Factors of Nodal Upstaging in Clinical Ia Lung Adenocarcinoma.
10.3779/j.issn.1009-3419.2018.06.07
- Author:
Yi QIN
1
;
Tong QIU
1
;
Yunpeng XUAN
1
;
Yandong ZHAO
1
;
Wenjie JIAO
1
Author Information
1. Department of Thoracic Surgery, the Affiliated Hospital, Qingdao University, Qingdao 266001, China.
- Publication Type:Journal Article
- Keywords:
Clinical early stage;
Lung neoplasms;
N upstaging;
Pathology;
Radiology
- MeSH:
Adenocarcinoma;
diagnosis;
pathology;
Adenocarcinoma of Lung;
Female;
Humans;
Lung Neoplasms;
diagnosis;
pathology;
Male;
Middle Aged;
Neoplasm Staging;
Prognosis;
Retrospective Studies;
Risk Factors
- From:
Chinese Journal of Lung Cancer
2018;21(6):463-469
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:In clinical Ia (cT1N0M0) patients, some may have poor prognosis, for it might occur pathologic N1 (pN1) or N2 (pN2) postoperatively. The aim of this study is to determine the radiologicaland pathological factors related to clinical Ia adenocarcinoma.
METHODS:The retrospective study was conducted on 297 clinical Ia adenocarcinoma patients resected at our hospital between May 2012 to December 2016. The clinical profiles, radiological and pathological features were analyzed between nodal upstaging group and non-upstaging group.
RESULTS:Of 297 patients treated for cN0 tumors, 250 cases (84.2%) were confirmed postoperatively as having pN0 tumors, and 47 (15.8%) were confirmed as having pN1 or pN2 tumors. Female, low smoking index, micropapillary predominant and solid predominant adenocarcinoma, puresolid tumor and large tumor size were all more frequently seen in the nodal upstaging group than in the pN0 group (P<0.05). Logistic regression indicate that radiological solid tumor, micropapillary predominant and solid predominant adenocarcinoma and vessel invasionare the risk factors of nodal upstaging in clinical Ia adenocarcinoma.
CONCLUSIONS:Radiological solid tumors, micropapillary predominant and solid predominant adenocarcinoma andvessel invasion are risk factors for nodal upstaging for early stage lung cancer. Radiological solid tumors should perform SLND in Ia adenocarcinomas.
