Association between EGFR, ALK and KRAS Gene Status and Synchronous Distant
Organ Metastasis in Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2018.07.06
- Author:
Ge GAO
1
;
LiLi DENG
1
Author Information
1. Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Chinaa.
- Publication Type:Journal Article
- Keywords:
ALK;
EGFR;
KRAS;
Lung neoplasms;
Metastasis
- MeSH:
Anaplastic Lymphoma Kinase;
Carcinoma, Non-Small-Cell Lung;
genetics;
pathology;
ErbB Receptors;
genetics;
Humans;
Lung Neoplasms;
genetics;
pathology;
Neoplasm Metastasis;
Proto-Oncogene Proteins p21(ras);
genetics;
Receptor Protein-Tyrosine Kinases;
genetics
- From:
Chinese Journal of Lung Cancer
2018;21(7):536-542
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the leading cause of morbidity and mortality of malignant diseases in China. Approximately 57% lung cancer patients harbored distant metastases at initial diagnosis which is relevant to poor outcomes. The research strategy of anti-lung cancer metastasis now has became the new treatment directions and thoughts for lung cancer treatment. Previous studies have shown that changes in the corresponding driving genes on different signaling pathways may be related to the transfer of different organs, and the biological alteration of tumor to some extent can affect the metastatic behavior and metastatic pattern of tumor. However, current clinical and basic studies have not elucidated the molecular mechanism of the specific distant organ metastasis in the pathway of lung cancer related signal transduction, clinical research on the correlation between gene mutation and organ transfer specificity is also relatively rare. This review aims to summarize the characteristics of the expression of epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue (KRAS) in non-small cell lung cancer, and the correlation between the distribution of metastatic organs.
.
