Value of Coagulation and Fibrinolysis Biomarker in Lung Cancer Patients with Thromboembolism.
10.3779/j.issn.1009-3419.2018.08.03
- Author:
Yang FU
1
;
Yumei LIU
1
;
Yaxiong JIN
1
;
Hong JIANG
1
Author Information
1. Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- Keywords:
Coagulation biomarker;
Diagnosis power;
Fibrinolysis biomarker;
Lung neoplasms;
Thrombosis
- MeSH:
Biomarkers;
metabolism;
Blood Coagulation;
Female;
Fibrinolysis;
Humans;
Lung Neoplasms;
complications;
metabolism;
physiopathology;
Male;
Middle Aged;
Thromboembolism;
complications
- From:
Chinese Journal of Lung Cancer
2018;21(8):583-587
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Coagulation and fibrinolysis biomarkers can effectively reflect the dysfunction of coagulation and anticoagulation system, and the changes of their levels were closely related to the hypercoagulable status. The aim of this study is to study the variation tendency of these coagulation and fibrinolysis markers and explore the diagnosis power and clinical value of these biomarker for thrombosis in postoperative lung cancer patients with deep vein catheterization.
METHODS:We selected 118 postoperative lung cancer patients with deep vein catheterization including 29 patients with thromboembolism and 89 patients in control group. Coagulation and fibrinolysis parameters [thrombomodulin (TM)/thrombin-antithrombin complex (TAT)/α2-plasmin inhibitor-plasmin complexes (PIC)/tissue plasminogen activator-inhibitor complexes (t-PAIC)] and traditional coagulation time[prothrombintime (PT)/activated partial thrombo plastin time(APTT)/thrombintime (TT)/fibrinogen (FIB)/antithrombin III (ATIII)/fibrinogen degradation products (FDP)/D-Dimer (D-D)] were detected in both groups. We analyzed the variation tendency of these biomarkers and figured out the diagnosis powerfor thrombosis.
RESULTS:A statistically significant difference was available on the value of TM, TAT, PIC, t-PAIC, D-D, FDP between thrombosis group and non-thrombosis group (P<0.05). TM, TAT, PIC, t-PAIC, D-D, FDP performed with an AUC of 0.770, 0.771, 0.669, 0.671, 0.819, 0.816, respectively (P<0.05).
CONCLUSIONS:An enhanced coagulation and fibrinolysis activity existed in lung cancer patients with deep vein catheterization after surgery, and early detection of coagulation and fibrinolytic biomarkers could prevent thrombosis and reduce postoperative thrombosis complications in patients with lung cancer.
