Progress of Liquid Biopsy in Early Diagnosis of Lung Cancer.
10.3779/j.issn.1009-3419.2018.08.08
- Author:
Zhipeng SONG
1
;
Yang LIU
1
Author Information
1. Department of Epidemiology, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
- Publication Type:Journal Article
- Keywords:
Circulating tumor DNA;
Circulating tumor cells;
Diagnosis;
Exosomes;
Liquidbiopsy;
Lung neoplasm;
MicroRNA;
Tumor educated platelets
- MeSH:
Early Detection of Cancer;
methods;
Humans;
Liquid Biopsy;
methods;
Lung Neoplasms;
blood;
diagnosis;
pathology
- From:
Chinese Journal of Lung Cancer
2018;21(8):620-627
- CountryChina
- Language:Chinese
-
Abstract:
The early diagnosis of lung cancer can improve the survival rate of patients. Using imaging method to screen high-risk population plays an important role in early detection and early diagnosis. More and more research shows that liquid biopsy can replace and supplement the method. Detection of circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), microRNA (miRNA), exosomes, and tumor educated platelets (TEPs) in patients' peripheral blood can be used for the early diagnosis of lung cancer, and may provide appropriate medical advice for high-risk population with negative imaging finding. The full text reviews the detection methods of these markers, their value in the early diagnosis, as well as their advantages and limitations, in order to promote the application of liquid biopsy in the early diagnosis and other fields.
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