MicroRNA and Lung Cancer: A Mini Review.
10.3779/j.issn.1009-3419.2018.09.13
- Author:
Lei TUO
1
;
Xiaoshuai CHU
1
;
Sha SHA
1
;
Xun ZHANG
2
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Weifang Yidu Central Hospital, Weifang 262500, China.
2. Department of Thoracic Surgery, Tianjin Chest Hosptial, Tianjin 300051, China.
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
MicorRNA;
Molecular mechanism
- MeSH:
Humans;
Lung Neoplasms;
diagnosis;
genetics;
pathology;
MicroRNAs;
genetics;
Neoplasm Invasiveness;
Neoplasm Metastasis
- From:
Chinese Journal of Lung Cancer
2018;21(9):727-730
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) a class of non-coding RNAs about 22 nt in size that are found in a wide range of organisms from plants, viruses to humans. MicroRNA has a wide range of biological functions. It can recruit related RNA enzymes and lead to mRNA degradation after binding to mRNA specificity, thus blocking the expression of protein encoding genes and then affecting their biological functions. In recent years, microRNA has been found to be closely related to the biological behaviors, such as the occurrence, development, invasion and metastasis of multiple human malignant carcinomas, and play a regulatory role in the above biological phenotypes. Lung cancer is the highest incidence of malignancy. The exact molecular mechanism of its occurrence and development has not been fully elucidated. Previous studies have shown that microRNA plays an important role in lung tumor suppressor gene inactivation, oncogene activation and epigenetics. At the same time, there are also reports that there is a significant difference in the expression of microRNA in patients with lung cancer and benign lung diseases. This differential expression provides a basis for the feasibility of microRNA as a diagnostic and pre biological marker for lung cancer.
.
