Research Advances of Ang-2 in Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2018.11.09
- Author:
Xin HUA
1
;
Xiaoli ZHU
2
Author Information
1. Medical College of Southeast University, Affiliated Zhongda Hospital of Southeast University,
Nanjing 210000, China.
2. Department of Respiration, Affiliated Zhongda Hospital of Southeast University,
Nanjing 210000, China.
- Publication Type:Journal Article
- Keywords:
Angiogenesis;
Angiopoietin-2;
Invasion and metastasis;
Lung neoplasms
- MeSH:
Angiopoietin-2;
genetics;
metabolism;
Carcinoma, Non-Small-Cell Lung;
drug therapy;
genetics;
metabolism;
pathology;
Gene Expression Regulation, Neoplastic;
drug effects;
Humans;
Lung Neoplasms;
drug therapy;
genetics;
metabolism;
pathology;
Molecular Targeted Therapy;
Signal Transduction;
drug effects
- From:
Chinese Journal of Lung Cancer
2018;21(11):868-874
- CountryChina
- Language:Chinese
-
Abstract:
Non-small cell lung cancer (NSCLC) is one of the malignant tumors with highest mortality in the world, it is still a difficult problem in clinical field. Its occurrence and development are closely associated with tumor angiogenesis. Angiopoietin-2 (Ang-2) is an important angiogenesis factor that has involved in many researches and it has been confirmed that the expression of Ang-2 is significantly up-regulated in tissues and blood of NSCLC. Meanwhile, Ang-2 is related to malignant biological behavior of cancer cells, making it a potential biological marker for the diagnosis and prognosis of NSCLC. At present, researches on Ang-2 how to promote the progression of NSCLC around the world are focused on Ang-2 regulating the proliferation, invasion, and metastasis of NSCLC. This paper summarized and estimated the studies and literature reports of regulatory mechanisms of Ang-2 in NSCLC, hopefully it could help looking for targeted drug treatment of Ang-2 in the future.
.
