Progress in Non-invasive Detection of EGFR Mutation in Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2018.12.09
- Author:
Shiyang YUAN
1
;
Yeqing ZOU
2
;
Junping XIE
1
Author Information
1. Department of Respiratory and Critical Care Medicine,
the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
2. Jiangxi Province Key Laboratory of Molecular Medicine,
the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
- Publication Type:Journal Article
- Keywords:
Epidermal growth factor receptor;
Exhaled condensate;
Liquid biopsy;
Lung neoplasms
- MeSH:
Animals;
Antineoplastic Agents;
administration & dosage;
Carcinoma, Non-Small-Cell Lung;
drug therapy;
genetics;
metabolism;
DNA Mutational Analysis;
methods;
ErbB Receptors;
genetics;
metabolism;
Humans;
Lung Neoplasms;
drug therapy;
genetics;
metabolism;
Mutation
- From:
Chinese Journal of Lung Cancer
2018;21(12):912-917
- CountryChina
- Language:Chinese
-
Abstract:
Over the past decade, the management model of cancer patients has gradually shifted to individual mode based on molecular mutation detection. Epidermal growth factor receptor (EGFR) gene mutation is an important driving factor in non-small cell lung cancer (NSCLC). Compared with traditional chemotherapy, EGFR-targeted therapy shows significant safety and efficacy. However, not all patients with EGFR mutations are eligible for EGFR-targeted therapy, and different types of mutations often indicate different clinical outcomes, such as the sensitive mutations EGFR 19-Del, L858R, and the resistance mutation. In addition, the third-generation TKI drugs Osimertinib (AZD9291) and Rociletinib (CO-1686) have been developed to further benefit patients with primary TKI resistance caused by T790M mutation of EGFR. Therefore, detection of the EGFR mutation status of patients before treatment, and continuously monitoring the mutation of drug resistance genes during the treatment process is useful for the management of targeted drugs in NSCLC patients. In recent years, the rapid development of "liquid biopsy" technology has made it possible to use non-invasive methods to monitor drug resistance mutations in real time. In this paper, we reviewed the clinical application of various non-invasive detection techniques for EGFR mutations in NSCLC in different liquid samples.
.
