In-vivo optical imaging in head and neck oncology: basic principles, clinical applications and future directions.
10.1038/s41368-018-0011-4
- Author:
Chenzhou WU
1
;
John GLEYSTEEN
2
;
Nutte Tarn TERAPHONGPHOM
3
;
Yi LI
4
;
Eben ROSENTHAL
5
Author Information
1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
2. Department of Otolaryngology, University of Tennessee Health Science Center, 38163, Memphis, TN, USA.
3. Department of Otolaryngology and Radiology, Stanford University, 94305, Stanford, CA, USA.
4. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. liyi1012@163.com.
5. Department of Otolaryngology and Radiology, Stanford University, 94305, Stanford, CA, USA. erosenthal@stanfordhealthcare.org.
- Publication Type:Journal Article
- MeSH:
Forecasting;
Head and Neck Neoplasms;
diagnostic imaging;
Humans;
Optical Imaging;
methods
- From:
International Journal of Oral Science
2018;10(2):10-10
- CountryChina
- Language:English
-
Abstract:
Head and neck cancers become a severe threat to human's health nowadays and represent the sixth most common cancer worldwide. Surgery remains the first-line choice for head and neck cancer patients. Limited resectable tissue mass and complicated anatomy structures in the head and neck region put the surgeons in a dilemma between the extensive resection and a better quality of life for the patients. Early diagnosis and treatment of the pre-malignancies, as well as real-time in vivo detection of surgical margins during en bloc resection, could be leveraged to minimize the resection of normal tissues. With the understanding of the head and neck oncology, recent advances in optical hardware and reagents have provided unique opportunities for real-time pre-malignancies and cancer imaging in the clinic or operating room. Optical imaging in the head and neck has been reported using autofluorescence imaging, targeted fluorescence imaging, high-resolution microendoscopy, narrow band imaging and the Raman spectroscopy. In this study, we reviewed the basic theories and clinical applications of optical imaging for the diagnosis and treatment in the field of head and neck oncology with the goal of identifying limitations and facilitating future advancements in the field.
